Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation

US6127407A · kind A · utility

Assignees

• Ion Pharmaceuticals, Inc. · US
• President and Fellows of Harvard College · US
• Children's Medical Center Corporation · US

Inventors

• Carlo Brugnara · Newton, US
• Jose Halperin · Brookline, US
• Rudolf Fluckiger · Brookline, US
• Emile Bellott · Beverly, US
• Richard John Lombardy · Littleton, US
• John J. Clifford · Arlington, US
• Ying-Duo Gao · Murfreesboro, US
• Reem M. Haidar · Woburn, US
• Eugene Kelleher · Somerville, US
• Adel Moussa · Burlington, US
• Yesh P. Sachdeva · Concord, US
• Minghua Sun · Libertyville, US
• Heather N. Taft · Littleton, US

Key dates

• Filing date: Nov 20, 1997
• Grant date: Oct 3, 2000
• Expiry date: Nov 20, 2017

Classification

• Technology area (CPC —): General

Abstract

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.