Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors

US6127545A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Philip Pye · Guttenberg, US
• Kai Rossen · Hanau, DE
• Ashok J. Maliakal · Westfield, US
• Ralph P. Volante · Rahway, US
• Jess Sager · Bound Brook, US
• Jean-Francois Marcoux · Westfield, US
• Ian Davies · Princeton, US
• Edward G. Corley · Old Bridge, US
• Daniel R. Sidler · Whitehouse Station, US
• Robert D. Larsen · Bound Brook, US

Key dates

• Filing date: Sep 18, 1998
• Grant date: Oct 3, 2000
• Expiry date: Sep 18, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/50
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##