2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents

US6127554A · kind A · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Georgia State University · US

Inventors

• David W. Boykin · Atlanta, US
• Richard R. Tidwell · Pittsboro, US
• W. David Wilson · Atlanta, US
• Iris Francesconi · Atlanta, US

Key dates

• Filing date: May 14, 1999
• Grant date: Oct 3, 2000
• Expiry date: May 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/54
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylaminoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treatment.