Vascular endothelial growth factor C (VEGF-C) .DELTA.Cys.sub.156 protein and gene, and uses thereof
US6130071A · kind A · utility
84Cited by
7References
29Claims
0Family size
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Key dates
| Filing date | Feb 5, 1997 |
| Grant date | Oct 10, 2000 |
| Priority date | — |
| Expiry date | Feb 5, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.