Antiviral methods
US6130202A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1994 |
| Grant date | Oct 10, 2000 |
| Priority date | — |
| Expiry date | Apr 14, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/1774
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for inhibiting infectivity and reducing infection by human rhinovirus (HRV) of host cells susceptible to infection by HRV and methods of inhibiting initiation and spread of the common cold, said methods comprising contacting HRV under conditions favorable for binding with a multimeric antiviral agent comprising two or more units wherein said units may be the same or different and are each independently selected from the group consisting of transmembrane intercellular adhesion molecule-1 (tmICAM-1) and truncated forms of intercellular adhesion molecule-1 (tICAMs), each of said units containing at least one unpaired cysteine residue at a position selected from the group consisting of 307 and 309, wherein each of said units is linked to at least one other of said units via a disulfide bridge, and wherein said multimeric antiviral agent binds to HRV and reduces infectivity thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.