Polymorphic form of doxazosin mesylate (Form I)

US6130218A · kind A · utility

Assignee

• Heumann Pharma GmbH · DE

Inventors

• Johann Peter Morsdorf · Langenzenn, DE
• Ingomar Grafe · Nürnberg, DE

Key dates

• Filing date: Dec 17, 1997
• Grant date: Oct 10, 2000
• Expiry date: Dec 17, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterized in its X-ray spectrum by the following reflex positions of high and medium intensity: 15.40.degree., 16.85.degree., 18.06.degree., 24.15.degree. and 25.81.degree.. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and pharmaceutical compositions comprising the new form of doxazosin mesylate are also described.