4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

US6130234A · kind A · utility

Assignees

• WARNER-LAMBERT COMPANY LLC · US
• Cocensys, Incorporated · US

Inventors

• Christopher Franklin Bigge · Ann Arbor, US
• Jonathan Wright · Ann Arbor, US
• Sui Xiong Cai · San Diego, US
• Eckard Weber · San Diego, US
• Richard Woodward · Phoenixville, US
• Nancy C. Lan · Altadena, US
• Zhang-Lin Zhou · Irvine, US
• John F. W. Keana · Eugene, US

Key dates

• Filing date: Dec 20, 1996
• Grant date: Oct 10, 2000
• Expiry date: Dec 20, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.