Patent · US Expired

Peptidase inhibitors

US6130315A · kind A · utility

17Cited by

7References

18Claims

0Family size

Assignee

Merrell Pharmaceuticals, Inc. · US

Inventors

H. Michael Kolb · Cincinnati, US
Joseph P. Burkhart · Plainfield, US
Michael J. Jung · Saverne, FR
Fritz Gerhart · Kehl, DE
Eugene L. Giroux · Strasbourg, FR
Bernhard Neises · Griesheim, DE
Daniel Schirlin · Schiltigheim, FR

Key dates

Filing date	Aug 24, 1998
Grant date	Oct 10, 2000
Priority date	—
Expiry date	Aug 24, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.