Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system

US6133239A · kind A · utility

Assignees

• The Biomembrane Institute · US
• SEIKAGAKU CORPORATION · JP

Inventors

• Kazuko Handa · Seattle, US
• Mary Ellen K. Salyan · Silverdale, US
• Mark Stroud · Seattle, US
• Sen-itiroh Hakomori · Seattle, US

Key dates

• Filing date: Jul 29, 1996
• Grant date: Oct 17, 2000
• Expiry date: Jul 29, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H3/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.