Certain pyrrolopyridine derivatives; novel CRF1 specific ligands
US6133282A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1999 |
| Grant date | Oct 17, 2000 |
| Priority date | — |
| Expiry date | Aug 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the formula: ##STR1## wherein Ar is optionally substituted aryl or heteroaryl PA1 R.sub.1 is hydrogen or alkyl; PA1 R.sub.7 is hydrogen or alkyl; PA1 R.sub.2 is hydrogen, halogen, alkyl or alkoxy; or PA1 R.sub.1 and R.sub.2 taken together with the ring to which they are attached form a 5-9 membered saturated or aromatic ring optionally having a hetero atom selected from oxygen, sulfur or nitrogen; PA1 R.sub.3 and R.sub.4 are independently hydrogen, alkyl, cycloalkyl, aryl or heteroaryl groups; or PA1 R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form a 5-8 membered ring; and PA1 R.sub.5 is hydrogen, halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy or thioalkoxy having 1-6 carbon atoms, PA1 which compounds are highly selective partial agonists or antagonists at human Corticotropin-Releasing Factor 1 (CRF1) receptors and are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.