Piperidine-indole compounds having 5-HT.sub.6 affinity
US6133287A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 1998 |
| Grant date | Oct 17, 2000 |
| Priority date | — |
| Expiry date | Mar 24, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/454
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compounds with affinity for the 5-HT.sub.6 receptor, which have the general formula: wherein: PA1 R.sup.1 is selected from the group consisting of H and C.sub.1-4 alkyl; PA1 R.sup.2 is selected from the group consisting of H, C.sub.1-4 alkyl and benzyl; PA1 -- -- -- represents a single or double bond; PA1 R.sup.3 is selected from the group consisting of COR.sup.5 and SO.sub.2 R.sup.5 ; PA1 R.sup.4a is selected from the group consisting of H, OH, halo, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; PA1 R.sup.4b is selected from the group consisting of H, hydroxy, halo, C.sub.3-7 cycloalkyloxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; PA1 R.sup.4c is selected from the group consisting of H, OH, halo, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; PA1 R.sub.4d is selected from the group consisting of H, OH, halo, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; and PA1 R.sup.5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C.sub.1-4 alkoxy, C.sub.1-4 alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy,…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.