Amidino protease inhibitors

US6133315A · kind A · utility

Assignee

• 3-Dimensional Pharmaceuticals, Inc. · US

Inventors

• Tianbao Lu · Collegeville, US
• Bruce E. Tomczuk · Richmond, US
• Carl R. Illig · Phoenixville, US
• Richard Soll · San Diego, US

Key dates

• Filing date: Mar 16, 1999
• Grant date: Oct 17, 2000
• Expiry date: Mar 16, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R.sup.1 -R.sup.4, R.sup.6 -R.sup.9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.