Recombinant anti-CD4 antibodies for human therapy
US6136310A · kind A · utility
64Cited by
4References
16Claims
0Family size
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Key dates
| Filing date | Sep 6, 1995 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Sep 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties including low antigenicity, reduced (or absent) T cell depleting activity, good affinity to human CD4 and enhanced stability (in vivo half-life).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.