Bacterial plasmin receptors as fibrinolytic agents
US6136323A · kind A · utility
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1Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 11, 1994 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Jul 11, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns novel methods and compositions for thrombolytic therapy. More specifically, a receptor with high affinity for plasmin has been characterized, purified, cloned, and expressed. This receptor can be used in combination therapies where it is administered prior to, concurrently with, or after a plasminogen activator. Also, this receptor can be bound to plasmin and administered to humans or animals in need of fibrinolytic activity. Additionally, the invention pertains to a novel immobilized form of plasmin which advantageously accumulates at the point where antifibrinolytic activity is needed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.