Methods of reducing the levels of protoporphyrin IX in recombinant hemoglobin preparations
US6136565A · kind A · utility
60Cited by
2References
13Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 18, 1999 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Oct 18, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to recombinant hemoglobin solutions containing reduced amounts of protoporphyrin IX and to methods of producing such hemoglobin solutions. The methods are accomplished by overexpressing the hemH gene in a suitable host cell or by increasing the production of hemH in a host cell, for example, by integration of the hemH gene into the chromosome of the host cell or by inserting multiple copies of the gene in host cells naturally having a hemH gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.