Carbohydrate mimetics having antiadhesive properties

US6136790A · kind A · utility

Assignee

• GLYCOREX AB · SE

Inventors

• Alexander Toepfer · Hofheim, DE
• Gerhard Kretzschmar · Eschborn, DE
• Eckart Bartnik · Hochheim, DE
• Dirk Seiffge · Hochheim, DE

Key dates

• Filing date: Jul 28, 1997
• Grant date: Oct 24, 2000
• Expiry date: Jul 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G73/0611
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their derivatives which, instead of an N-acetyl group, carry the substituents N.sub.3, NH.sub.2 or OH or which, instead of fucose, carry glycerol, and pharmaceutical compositions and diagnostic agents containing these derivatives, and methods for using these pharmaceutical compositions and diagnostic agents.