Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
US6136815A · kind A · utility
4Cited by
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8Claims
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Key dates
| Filing date | Nov 10, 1998 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Nov 10, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
6-aryloxy and 6-arylcarbonyl 2,4-pyrimidinedione derivatives of the formula(I) having high antiviral activity against HIV-1 and low toxicity are useful for treating AIDS: ##STR1## wherein: R.sup.1 is hydrogen or a C.sub.1-10 alkyl group optionally having a substituent selected from the group consisting of aryl, hydroxy, C.sub.1-10 alkoxy and C.sub.2-5 alkylcarbonyloxy groups; PA1 R.sup.2 is hydrogen or a C.sub.1-10 alkyl group optionally having an aryl substituent; PA1 R.sup.3 and R.sup.4 are each hydrogen or a C.sub.1-3 alkyl group; and PA1 A is oxygen or a carbonyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.