Sordarin derivatives
US6136853A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1999 |
| Grant date | Oct 24, 2000 |
| Priority date | — |
| Expiry date | Mar 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N63/30
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
PURPOSE: To produce a novel antibiotic substance zofimarin having antimicrobial activity against fungi and obtain an antimicrobial agent containing the antibiotic substance zofimarin as an active constituent, by cultivating a microorganism, belonging to the genus Zopfiella and capable of producing the zofimarin. CONSTITUTION: An ascomycete belonging to the genus Zopfiella, e.g. Zopfiella marina; is cultivated. The cultivation is carried out according to general fungi, but artifical seawater is used in place of tap water in a liquid culture medium. A carbon source, nitrogen source, inorganic salt, etc., are added, and a defoaming agent is suitably used to carry out the cultivation at 20-30.degree. C. by the spinner culture method with aeration. After completing the cultivation, microbial cells are removed, and the resultant product in the supernatant liquid or filtrate is extracted and purified to afford the aimed zofimarin. The above-mentioned antibiotic substance is neutral colorless oily substance exhibiting the following properties; Soluble in methanol, ethanol and acetone and slightly soluble in water. Positive to the color reaction with iodine and sulfuric acid, etc., and expr…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.