Antibodies which bind granulocyte-macrophane colony-stimulating factor receptor

US6136957A · kind A · utility

Assignee

• AMRAD Corporation Limited · AU

Inventors

• Nicos A. Nicola · Melbourne, AU
• Nicholas Martin Gough · Melbourne, AU
• David Gearing · Melbourne, AU
• Donald Metcalf · Melbourne, AU
• Julie Ann King · Melbourne, AU

Key dates

• Filing date: Jul 16, 1997
• Grant date: Oct 24, 2000
• Expiry date: Jul 16, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/77
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a recombinant or synthetic receptor or a derivative thereof, for granulocyte-macrophage colony-stimulating factor (GM-CSF). The GM-CSF receptor is useful, inter alia, in the treatment or diagnosis of GM-CSF-related diseases, and in the screening of agonists and antagonists of GM-CSF receptors. The invention further provides antibodies directed against GM-CSF receptor or derivatives thereof, and pharmaceutical compositions comprising either the GM-CSF receptor, the receptor derivative, or an antibody thereto, and methods of using thereof.