Camptothecin analogs and methods of preparation thereof

US6136978A · kind A · utility

Assignee

• UNIVERSITY OF PITTSBURGH · US

Inventors

• Dennis P. Curran · Pittsburgh, US
• Hubert Josien · Hoboken, US
• David C. Bom · Broadview Heights, US
• Thomas Burke · Lexington, US

Key dates

• Filing date: Dec 15, 1998
• Grant date: Oct 24, 2000
• Expiry date: Dec 15, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/083
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound and a method of synthesizing a compound having the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxy group, an aryloxy group, an acyloxy group, --OC(O)OR.sup.d, wherein R.sup.d is an alkyl group, a carbamoyloxy group, a halogen, a hydroxy group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, an acyl group, an amino group, --SR.sup.c, wherein, R.sup.c is hydrogen, an acyl group, an alkyl group, or an aryl group, or R.sup.1 and R.sup.2 together form a group of the formula --O(CH.sub.2).sub.n O-- wherein n represents the integer 1 or 2; R.sup.3 is H, F, a halogen atom, a nitro group, an amino group, a hydroxy group, or a cyano group; or R.sup.2 and R.sup.3 together form a group of the formula --O(CH.sub.2).sub.n O-- wherein n represents the integer 1 or 2; R.sup.4 is H, a trialkylsilyl group, F, a C.sub.1-3 alkyl group, a C.sub.2-3 alkenyl group, a C.sub.2-3 alkynyl group, or a C.sub.1-3 alkoxy group; R.sup.5 is a C.sub.1-10 alkyl group, an allyl group, a benzyl group or a propargyl group;…