Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith

US6140050A · kind A · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Ugur Sahin · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Yao-Tseng Chen · New York, US
• Lloyd J. Old · New York, US
• Michael Pfreundschuh · Homburg, DE

Key dates

• Filing date: Jun 26, 1998
• Grant date: Oct 31, 2000
• Expiry date: Jun 26, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/106
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.