Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3

US6140064A · kind A · utility

Assignee

• Theodor-Kocher Institute · SE

Inventors

• Marcel Loetscher · Oberwil, CH
• Bernhard Moser · Altshausen, DE

Key dates

• Filing date: Sep 10, 1996
• Grant date: Oct 31, 2000
• Expiry date: Sep 10, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.