Adenovirus vectors for gene therapy

US6140087A · kind A · utility

Assignee

• AdVec, Inc. · CA

Inventors

• Frank L. Graham · Hamilton, CA
• Andrew J. Bett · Lansdale, US
• Ludvik Prevec · Burlington, CA
• Wael M. Haddara · Kingston, CA

Key dates

• Filing date: May 31, 1994
• Grant date: Oct 31, 2000
• Expiry date: May 31, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and also insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention includes the use of the vectors in introducing genes into cells, in making vaccines and in gene therapy.