Colon or ileum-specific glucocorticosteroid derivatives

US6140308A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Ralph Lennart Brattsand · Lund, SE
• Peter Edman · Ulricehamn, SE
• Thomas Hogberg · Gately Drive, SE
• Stinabritt Nilsson · Lund, SE
• Bror Arne Thalen
• Jan Ulmius · Lund, SE

Key dates

• Filing date: Mar 3, 1999
• Grant date: Oct 31, 2000
• Expiry date: Mar 3, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula EQU GCS.sup.1 --O--Sugar.sup.1 for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their preparation, pharmaceutical preparations containing the compounds and the use of said compounds in therapy.