Heterocyclic cytotoxic agents

US6140328A · kind A · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Edmond J. LaVoie · Princeton Junction, US
• Darshan B. Makhey · Highland Park, US
• Baoping Zhao · Shanghai, CN
• Leroy F. Liu · Bound Brook, US

Key dates

• Filing date: Dec 12, 1997
• Grant date: Oct 31, 2000
• Expiry date: Dec 12, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula I: wherein PA1 R.sub.1 -R.sub.8 and X and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.