Carbazolyl-substituted ethanolamines as selective .beta.-.sub.3 agonists

US6140352A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Thomas Alan Crowell · Indianapolis, US
• Deborah A. Evrard · Indianapolis, US
• Charles D. Jones · Indianapolis, US
• Brian S. Muehl · Indianapolis, US
• Christopher J. Rito · Mooresville, US
• Anthony John Shuker · Indianapolis, US
• Andrew Thorpe · Ann Arbor, US
• Kenneth Jeff Thrasher · Indianapolis, US

Key dates

• Filing date: May 4, 1998
• Grant date: Oct 31, 2000
• Expiry date: May 4, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are selective beta 3 adrenergic agonists represented by the following structural formula: ##STR1## The variables in the structural formula shown above are defined in the specification. Also disclosed are methods of using these compounds for agonizing the beta 3 adrenergic receptor in patients in need of such treatment, for example, patients in need of treatment for obesity or Type II diabetes.