Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof
US6140361A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 22, 1999 |
| Grant date | Oct 31, 2000 |
| Priority date | — |
| Expiry date | Mar 22, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/163
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.