Precursors for deoxyribonucleotides containing non-standard nucleosides
US6140496A · kind A · utility
Inventor
Key dates
| Filing date | Dec 31, 1996 |
| Grant date | Oct 31, 2000 |
| Priority date | — |
| Expiry date | Dec 31, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/915
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The disclosure describes building blocks for preparing oligonucleotides carrying non-standard nucleobases that can pair with complementary non-standard nucleobases so as to fit the Watson-Crick geometry, in that the resulting base pair joins a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six member ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.