Substituted [2-(1-piperazinyl)ethoxy]methyl compounds
US6140501A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 9, 1998 |
| Grant date | Oct 31, 2000 |
| Priority date | — |
| Expiry date | Oct 9, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/205
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel substituted [2-(1-piperazinyl)ethoxy]methyl compounds. The present invention related to novel substituted [2-(1-piperazinyl)-ethoxy]methyl compounds of formula ##STR1## in which R.sub.1 represents a --CONH.sub.2, --CN, --COOH, --COOM or --COOR.sub.3 group, M being an alkali metal and R.sub.3 being an alkyl radical having from 1 to 4 carbon atoms; and PA1 R.sub.2 represents a hydrogen atom or a group --COR.sub.4 or --R.sub.5, where R.sub.4 is chosen from the groups --OR.sub.6 or --R.sub.7, in which PA2 R.sub.5 represents an allyl or alkylaryl radical, PA2 R.sub.6 represents a linear or branched alkyl radical having from 1 to 4 carbon atoms, a haloalkyl, alkylaryl, alkylnitroaryl or alkylhaloaryl radical, and PA2 R.sub.7 represents a haloalkyl radical, to a process for the preparation of these compounds, and to their use for the preparation of compounds which are themselves valuable intermediates for the preparation of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid or 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-acetic acid and/or pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.