Process for the preparation of 4-(des-dimethylamino)-tetracyclines
US6143161A · kind A · utility
15Cited by
2References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 24, 1999 |
| Grant date | Nov 7, 2000 |
| Priority date | — |
| Expiry date | May 24, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention refers to a process for the preparation of 4-(des-dimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(des-dimethylamino)-tetracyclines are isolated by extraction with an organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.