Methods for modulating T cell survival by modulating bcl-X.sub.L protein level
US6143291A · kind A · utility
9Cited by
0References
5Claims
0Family size
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Nov 7, 2000 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-X.sub.L protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-X.sub.L protein level in the T cell. Both in vivo and in vitro methods are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.