Controlled release liquid delivery compositions with low initial drug burst

US6143314A · kind A · utility

Assignee

• Atrix Laboratories, Inc. · US

Inventors

• Bhagya L. Chandrashekar · Fort Collins, US
• Mingxing Zhou · Fort Collins, US
• Eileen M. Jarr · Fort Collins, US
• Richard L. Dunn · Fort Collins, US

Key dates

• Filing date: Oct 28, 1998
• Grant date: Nov 7, 2000
• Expiry date: Oct 28, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/0024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.