Patent · US Expired

UDP-glucose pyro phosphorylase enzymes from nonparasitic protozoa

US6143539A · kind A · utility

2Cited by

0References

5Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Thomas Kiy · Frankfurt, DE
Lothar Elling · Aachen, DE
Maria-Regina Kula · Jülich, DE

Key dates

Filing date	Mar 3, 1997
Grant date	Nov 7, 2000
Priority date	—
Expiry date	Mar 3, 2017

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/947
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to nucleotide-sugar-synthesizing enzymes (enzymes with nucleotidyltransferase or pyrophosphorylase activity) from nonparasitic protists, to a process for the preparation thereof and to the use thereof for preparing nucleotide-sugars. The enzymes according to the invention make possible or greatly simplify the enzymatic preparation of various nucleotide-sugars on the industrial scale from low-cost precursors. It is possible with the aid of the discovered enzymes to prepare, for example, GDP-fucose, GDP-mannose, UDP-glucose, UDP-glucosamine, UDP-galactose, UDP-galactosamine, UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in economic quantities.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.