Dolastatin 15 derivatives

US6143721A · kind A · utility

Assignee

• BASF SE

Inventors

• Bernd Janssen · Ludwigshafen, DE
• Teresa Barlozzari · Wellesley, US
• Andreas Haupt · Ludwigshafen, DE
• Thomas Zierke · Böhl-Iggelheim, DE
• Andreas Kling · Mannheim, DE

Key dates

• Filing date: Jul 18, 1997
• Grant date: Nov 7, 2000
• Expiry date: Jul 18, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, EQU A-B-D-E-F-(G).sub.r -(K).sub.s -L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are .alpha.-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a .beta.-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.