Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
US6143866A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1995 |
| Grant date | Nov 7, 2000 |
| Priority date | — |
| Expiry date | Jan 19, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from urine is disclosed. The deglycosylated form of the 3O kDa TNF inhibitor and 40 kDa TNF inhibitor are described as being active against TNF. The 40 kDa TNF inhibitor is active against both TNF alpha a TNF beta. The amino acid sequence of the 30 kDa TNF inhibitor and the 40 kDa TNF inhibitor are disclosed. Methods for isolating the TNF inhibitors from human U937 cell medium and producing the proteins by recombinant-DNA methods are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.