Preparation of [1S-[1A,2B,3B,4A(S*)]]-4-[7-[[1-(3-chloro-2-thienyl)methyl propyl]amino] -3H-imidazo[4,5-B]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxa mide

US6143894A · kind A · utility

Assignee

• Aventis Pharmaceuticals Products Inc. · US

Inventors

• Michael K. O'Brien · Berwyn, US
• Herve Garcia · Saint-Fons, FR
• Patrick Leon · Tassin-la-Demi-Lune, FR
• Tory H. Powner · Chester, US
• Laurence W. Reilly, Jr. · Yorktown Heights, US
• Harshavadan C. Shah · Secane, US
• Michael D. Thompson · San Diego, US
• Ching T. Tsuei · Lansdale, US
• Benoit J. Vanasse · Collegeville, US
• Francis L. Walther · Wilmington, US

Key dates

• Filing date: Jan 19, 1999
• Grant date: Nov 7, 2000
• Expiry date: Jan 19, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxyc yclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.