Contrast agents for image enhancement in magnetic resonance imaging

US6146615A · kind A · utility

Assignees

• The University of Toledo · US
• SCHERING CORPORATION · US

Inventors

• Julian Davies · Toledo, US
• Wolfgang Ebert · Krefeld, DE
• Bernd Raduechel · Berlin, DE

Key dates

• Filing date: Jan 11, 1999
• Grant date: Nov 14, 2000
• Expiry date: Jan 11, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/101
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.