Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
US6146902A · kind A · utility
72Cited by
4References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 29, 1998 |
| Grant date | Nov 14, 2000 |
| Priority date | — |
| Expiry date | Dec 29, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25375
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed and claimed are a method for the purification of polysaccharide-protein conjugate vaccines by ultrafiltration in a saturated solution of ammonium sulfate. The ultrafiltration method of the present invention provides an efficient, readily scalable method for removal of unbound polysaccharides from polysaccharide-protein vaccines, thereby improving the purity and consistency of the polysaccharide-protein vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.