Liposome encapsulated amphiphilic drug compositions

US6149937A · kind A · utility

Assignee

• VRIJE UNIVERSITEIT BRUSSEL · BE

Inventors

• Frederic Camu · Sint-Truiden, BE
• Mokarram Alafandy · Brussels, BE
• Robert Brasseur · Haillot, BE
• Franz Legros · Malmedy, BE
• Oliver Bouffioux · Andenne, BE

Key dates

• Filing date: Nov 19, 1998
• Grant date: Nov 21, 2000
• Expiry date: Nov 19, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1277
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the entrapment of amphiphilic compounds as uncharged or ionic with different mole ratios of phospholipid to the amphiphilic compound. Preparations of ionic species of amphiphilic compounds in the absence of crystals can be prepared, while preparations of uncharged amphiphilic compounds can be prepared with the compound exclusively entrapped inside the liposomes, or partly entrapped inside the liposomes with extraliposomal crystals.