Tat-SF: cofactor for stimulation of transcriptional elongation by HIV-1 Tat
US6150515A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1999 |
| Grant date | Nov 21, 2000 |
| Priority date | — |
| Expiry date | Aug 18, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16322
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention pertains to a novel transcriptional activity factor, Tat-Stimulatory Factor, as well as genes encoding this factor and fragments and biologically functional variants thereof. The Tat-Stimulatory Factor is involved in the regulation of transcriptional elongation of HIV-1 by Tat. The invention also pertains to therapeutics involving the foregoing proteins and genes, and agents that bind to the foregoing proteins and genes. The invention also relates to methods of screening for a compound which binds to Tat-SF1, Tat-SF1-associated kinase and/or a complex of Tat-SF1 and Tat-SF1-associated kinase, as well as methods of screening for compounds which modulate Tat-SF1-mediated transcriptional activation,
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.