Transgenic animals expressing artificial epitope-tagged proteins
US6150583A · kind A · utility
2Cited by
6References
2Claims
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Key dates
| Filing date | Feb 26, 1998 |
| Grant date | Nov 21, 2000 |
| Priority date | — |
| Expiry date | Feb 26, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2828
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA constructs are provided of epitope-tagged proteins or protein fragments which are conveniently purified with immunoaffinity chromatography such as epitope-tagged prion proteins (PrP). Transgenic animals expressing an epitope-tagged protein are provided, including transgenic animals expressing epitope-tagged PrP. Methods for distinguishing between the conformational shapes of a protein and a convenient method for isolating a tagged protein by immunoaffinity chromatographic methods are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.