Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
US6152881A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 29, 1999 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Mar 29, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/742
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The calibrated method for characterizing blood flow in a limb of a patient during reactive hyperemia utilizes a blood pressure cuff. The method establishes a predetermined, near diastolic, pressure in said blood pressure cuff during the reactive hyperemic episode, continually senses the pressure in the cuff and periodically changes the internal volume of said blood pressure cuff by a predetermined volumetric amount to calibrate the system. The resultant change in the pressure is a calibration pressure pulse and is used to calculates pulsatile blood volume through the blood vessel. A calibrated method for determining the condition of blood vessels and endothelium includes determining, for each calibration cycle, a respective peak value for the blood volume and comparing the peak blood volume values with peak blood volume values for healthy blood vessels and endothelium. The comparison preferably utilizes a waveform. The calibrated system for characterizing blood flow includes a computerized electronic and pneumatic system which inflates, for a predetermined pre-test time, the blood pressure cuff to a suprasystolic pressure and thereafter establishes the near diastolic pressure in th…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.