Treatment or prophylaxis of diseases caused by pilus-forming bacteria
US6153396A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 5, 1995 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Jun 5, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/849
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.