.alpha.(1,3) galactosyltransferase negative porcine cells
US6153428A · kind A · utility
61Cited by
1References
5Claims
0Family size
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Key dates
| Filing date | Mar 26, 1996 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Mar 26, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Transgenic swine in which the normal expression of .alpha.(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal.alpha.1-3Gal.beta.1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.