Methods of screening for agonists and antagonists for human CCR7 receptor and CK.beta.-9 ligand and interaction thereof
US6153441A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 1999 |
| Grant date | Nov 28, 2000 |
| Priority date | — |
| Expiry date | Feb 17, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are methods for discovering agonists and antagonists of the interaction between a secreted human protein, chemokine CK.beta.-9, and its cellular receptor, human CCR7, which may have utility in the treatment of several human diseases, including, but not limited to: allergic disorders, autoimmune diseases, ischemia/reperfusion injury, development of atherosclerotic plaques, cancer (including mobilization of hematopoietic stem cells for use in chemotherapy or mycloprotection during chemotherapy), chronic inflammatory disorders, chronic rejection of transplanted organs or tissue grafts, chronic myelogenous leukemia, and infection by HIV and other pathogens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.