Pharmaceutically active compounds

US6153641A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Håkan Bergstrand · Bjärred, SE
• Thomas Hogberg · Gately Drive, SE
• Kostas Karabelas · Lund, SE
• Anders Tunek · Malmö, SE

Key dates

• Filing date: Dec 18, 1997
• Grant date: Nov 28, 2000
• Expiry date: Dec 18, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides novel compounds of the formula (I): EQU R.sub.20 --(CH.sub.2).sub.n --R (I) wherein: PA1 T.sub.20 is a bisindolylmaleimide moiety linked to the --(CH.sub.2).sub.n -group through an indolyl nitrogen, PA1 n is 0 or 1, PA1 R is a 5 or 6 membered aromatic carbocyclic or heterocyclic ring, the heterocyclic ring containing N or S, PA1 R is substituted by R.sub.1 and up to four of R.sub.2, R.sub.3, R.sub.4 and R.sub.5, wherein; PA2 R.sub.1 is aminomethyl, (N--(C.sub.1-4 -alkyl)amino)methyl, (N,N-di(C.sub.1-4 -alkyl)amino)methyl or pyridiniummethyl, and PA2 R.sub.2, R.sub.3, and R.sub.4 and R.sub.5 (if present), which may be the same or different, are each hydrogen, hydroxy, C.sub.1-4 -alkoxy, C.sub.1-4 -alkoxy) or halogen, PA2 or R.sub.2 when in a position contiguous to the bond connecting R to the --(CH.sub.2).sub.n -- group and n is 1 may, together with the 2-carbon atom on the indole to which the --(CH.sub.2) group is attached, form a ring, and pharmaceutically acceptable salts thereof; and the use of such compounds in medical therapy.