Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol

US6156335A · kind A · utility

Assignee

• Rotta Research Laboratorium S.p.A. · IT

Inventors

• Luigi Rovati · Monza, IT
• Lucio Claudio Rovati · Monza, IT
• Francesco Makovec · Monza, IT
• Gunter Cordes · Leichlingen, DE
• Wilfried Fischer · Holzkirchen, DE

Key dates

• Filing date: Jul 15, 1994
• Grant date: Dec 5, 2000
• Expiry date: Jul 15, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is represented by a transdermal medicated patch for the extended release of 17.beta.-estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1% to 5% (w/w) 17.beta.-estradiol, and a protective liner which is removed before use. The matrix is formed of pressure-sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical copolymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5% (w/w) of other substances may be added.