Cross-linking tissue with a compound having a C.sub.8 to C.sub.40 aliphatic chain
US6156531A · kind A · utility
86Cited by
15References
25Claims
0Family size
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Key dates
| Filing date | Jul 20, 1998 |
| Grant date | Dec 5, 2000 |
| Priority date | — |
| Expiry date | Jul 20, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8 to 40 carbon atoms and two collagen-reactive groups such as isocyanate, epoxy or n-hydroxysuccinimide. The cross-linking agent may be produced by dimerizing fatty acids, and modifying carboxylic acid group of the fatty acids before or after dimerization to contain collagen-reactive groups. The cross-linked tissue has desirable mechanical and biocompatibility features and a reduced susceptibility to calcification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.