Epithelial adhesive lactobacilli

US6159465A · kind A · utility

Assignee

• PROBI AB · SE

Inventors

• Ingegerd Adlerberth · Handen, SE
• Siv Ahrne · Bjärred, SE
• Bengt Jeppsson · Lund, SE
• Marie Johansson · Watchung, US
• Goran Molin · Bjärred, SE
• Agnes Wold · Mölndal, SE

Key dates

• Filing date: Sep 23, 1997
• Grant date: Dec 12, 2000
• Expiry date: Sep 23, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention refers to the use of Lactobacillus plantarum 299v having a mannose-specific adhesin for the preparation of a pharmaceutical composition inhibiting the binding of pathogenic bacteria expressing mannose-specific adhesins to the epithelial cell surface. The strain of Lactobacillus plantiarum which can be used in the invention adheres to D-mannose-coated agarose beads. The invention also refers to the use of said strain for the preparation of a pharmaceutical composition to be used in prophylatic and/or curative treatment of bacterial translocation, gastroenteritis and other diseases caused by pathogenic bacteria expressing mannose-specific adhesins.