Application of enzyme prodrugs as anti-infective agents
US6159706A · kind A · utility
8Cited by
4References
1Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 18, 1998 |
| Grant date | Dec 12, 2000 |
| Priority date | — |
| Expiry date | Dec 18, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the resistance phenotype of the microbes. The invention further provides a method for selecting for antibiotic sensitivity, since a likely mechanism by which organisms are likely to gain resistance to the prodrugs is via loss of enzyme activity, which will make the bacteria sensitive to antibiotics once again.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.